As you come into Opuwo town from Windhoek on C41, you will see Opuwo Fire Station on the right and then SPAR on the left. At the traffic lights turn right onto Mbumbijazo Muharukua Street towards Okanguati.
Keep straight on for about one kilometre on C43.
After Opuwo Police Station, turn first left onto Rex Sheehama Street and drive straight on towards the Ministry of Youth and Sports. Simba Guesthouse Opuwo is about 500 metres up on the right.